DSPE-PEG-tri-GalNAc, MW 2,000 is a multivalent N-acetylgalactosamine-conjugated lipid composed of an O-deacetylated derivative of LNP GalNAc ligand 1, a GABA linker, a PEG-2000, and 1,2-distearoyl-rac-glycero-3-phosphoethanolamine. Multivalent GalNAc-conjugated lipids have been used in the generation of lipid nanoparticles (LNPs) for targeted liver delivery via the asialoglycoprotein receptor (ASGPR).
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