DOPE-C8 is a zwitterionic glycerophospholipid that has been used in the generation of lipid nanoparticles (LNPs) for mRNA delivery in vivo. LNPs containing DOPE-C8 have improved endosomal escape ability over LNPs containing 1,2-DSPC. LNPs containing DOPE-C8 and encapsulating mRNA encoding EGFP induce hepatic EGFP expression in mice.
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