Vinblastine sulfate is a highly potent, plant-derived tubulin polymerization inhibitor that disrupts microtubule assembly and induces M-phase cell cycle arrest, making it a well-validated cytotoxic agent for antibody–drug conjugate (ADC) development. Its nanomolar antiproliferative activity, defined tubulin-binding mechanism, and compatibility with chemical derivatization support its use as an effective payload in targeted ADC research and optimization.
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