N-(Azido-PEG8)-N-PEG8-t-butyl ester represents a branched PEG linker containing a t-butyl group, which can be hydrolyzed under acidic conditions to free the acid and an azide for click chemistry reactions with alkynes. The central secondary amine can undergo alkylation reactions with functional groups like activated halides or carboxylic acids. The PEG8 arms enhance the water solubility of the molecule. The branched nature of the linker allows for attachment of ADC payloads and antibodies.
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