Acid-PEG4-MMAF is an agent-linker combination designed for antibody-drug conjugates (ADCs), harnessing the robust antitumor efficacy of the potent anti-tubulin agent MMAF. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g., EDC or HATU). The hydrophilic PEG4 linker elevates the solubility of the molecule in aqueous media.
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