N-(Azido-PEG4)-N-bis-(PEG4-Val-Cit-PAB-MMAF) represents a branched PEG linker-payload that may be used in the creation of antibody-drug conjugates. The terminal azide partakes in click chemistry with BCN, DBCO, alkynes. The Val-Cit dipeptide is cleaved by cellular proteases like Cathepsin B within the cell to allow for efficient delivery of two MMAF payloads via an elimination mechanism within the PAB structure. Water solubility of the molecule is enhanced via the PEG spacers. The branched architecture supports attachment of ADC payloads or biomolecules.
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