DBCO-PEG3-aldehyde is a heterobifunctional linker featuring a DBCO moiety for copper-free click chemistry via strain-promoted azide–alkyne cycloaddition (SPAAC) and an aldehyde group for oxime or hydrazone ligation. The thermally stable DBCO group reacts rapidly and selectively with azides under mild, biocompatible conditions without requiring a copper catalyst. The hydrophilic PEG3 spacer enhances solubility, reduces steric hindrance, and minimizes aggregation, making it ideal for biological conjugation workflows.
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