DBCO-PEG4-HyNic is a heterobifunctional linker comprising a DBCO group for catalyst-free click chemistry via strain-promoted azide–alkyne cycloaddition (SPAAC) and a HyNic moiety for conjugation with aldehydes. The DBCO group is thermally stable and highly selective for azides, enabling efficient bioconjugation under physiological conditions.
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