acid-PEG8-Val-Cit-PAB-Exatecan represents a cleavable linker-payload used in the development of antibody-drug conjugates (ADCs). The Val-Cit is specifically cleaved by Cathepsin B for the intracellular release of the cytotoxic Exatecan, a structural analog of camptothecin that exhibits anticancer activity. The terminal carboxylic acid can be derivatized for further functionalization. The PEG8 chain improves the molecule's water solubility.
Usually ships within 24 hours.