N-(NHS-PEG8)-N-bis(PEG8-GGFG-Dxd) is a dual-payload linker that carries two DXd molecules. Built on a hydrophilic PEG8 chain with an NHS ester to conjugate with amine-containing molecules, it enables the attachment of both payloads in a single conjugation step. The GGFG peptide sequence serves as a protease-cleavable trigger, ensuring selective intracellular release of DXd. By delivering two identical cytotoxic payloads through one antibody, this dual-payload design enhances therapeutic potency, promotes synergistic effects, and supports the development of next-generation antibody–drug conjugates (ADCs).
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