N-(NHS-PEG8)-N-bis(PEG8-GGFG-Dxd) is a dual‑payload linker that carries two DXd molecules. Built on a hydrophilic PEG8 chain with an NHS ester to conjugate with amine-containing molecules, it enables the attachment of both payloads in a single conjugation step. The GGFG peptide sequence serves as a protease‑cleavable trigger, ensuring selective intracellular release of DXd. By delivering two identical cytotoxic payloads through one antibody, this dual‑payload design enhances therapeutic potency, promotes synergistic effects, and supports the development of next‑generation antibody–drug conjugates (ADCs).
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