N-(acid-PEG8)-N-bis(PEG8-GGFG-Dxd) is an advanced dual‑payload linker that carries two DXd molecules. Built on a PEG8 hydrophilic scaffold with an acid functional group for antibody conjugation, it enables the attachment of both payloads in a single conjugation step. The GGFG peptide sequence serves as a protease‑cleavable trigger, ensuring selective intracellular release of DXd. By delivering two identical cytotoxic payloads through one antibody, this dual‑payload design enhances therapeutic potency, promotes synergistic effects, and supports the development of next‑generation antibody–drug conjugates (ADCs).
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