SG3199-Val-Ala-PAB is a potent (pyrrolobenzodiazepine) PBD dimer prodrug linker-payload featuring a cleavable Val-Ala motif for lysosomal release. Upon activation, SG3199 induces irreversible DNA interstrand crosslinks in the minor groove, making it a key warhead for next-generation ADCs like Tesirine.
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