Fmoc-Val-Cit-PAB-Exatecan serves as a cleavable linker-payload intermediate for the synthesis of antibody-drug conjugates. The Val-Cit dipeptide is designed specifically to be cleaved by Cathepsin B, and the cytotoxic exatecan payload is for eliminating targeted tumor cells. The Fmoc group can be deprotected under basic conditions to obtain the free amine.
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