Tazemetostat is an orally bioavailable, S-adenosyl-L-methionine–competitive inhibitor of enhancer of zeste homolog 2 in Polycomb Repressive Complex 2, providing sub-20 nM blockade of histone H3-lysine-27 trimethylation and triggering apoptosis in SMARCB1-deleted cancers. Reagent-grade; for laboratory research purposes only.
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