Ritlecitinib

Ritlecitinib


Ritlecitinib (PF-06651600) is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC50 = 33 nM) with no significant activity against JAK1, JAK2, or TYK2 (IC50 >10 µM). It blocks signaling mediated by γ-chain cytokines such as IL-2 and IL-15 by inhibiting downstream STAT phosphorylation. Ritlecitinib suppresses Th1 and Th17 cell differentiation and demonstrates efficacy in preclinical models of autoimmune diseases including alopecia areata, adjuvant-induced arthritis, and experimental autoimmune encephalomyelitis.

Molecular structure of the compound BP-44053
    • Unit
    • Price
    • Qty
    • 100 MG
    • $120.00
    • 250 MG
    • $210.00
    • 500 MG
    • $320.00
    • 1 G
    • $540.00

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