Selpercatinib (LOXO-292) is a potent, selective RET tyrosine kinase inhibitor with antineoplastic activity. Demonstrates nanomolar potency against wild-type RET (IC50=14.0nM) and maintains activity against clinically relevant mutations V804M (IC50=24.1nM) and G810R (IC50=530.7nM). Reagent-grade; for laboratory research purposes only.
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