PTAD-PEG4-alkyne is a heterobifunctional linker designed for highly selective tyrosine bioconjugation. It features a PTAD moiety for metal-free, chemoselective modification of tyrosine residues and a terminal alkyne handle for subsequent CuAAC click chemistry. The PEG4 spacer enhances aqueous solubility, reduces steric hindrance, and improves conjugation efficiency. PTAD-mediated tyrosine linkages are more stable than maleimides, tolerating heat, extreme pH, and human plasma, making PTAD-PEG4-alkyne well suited for modifying peptides, proteins, and small molecules in advanced bioconjugation workflows.
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