PTAD-azide is a heterobifunctional linker featuring a PTAD moiety for selective tyrosine click reactions and an azide group for further click chemistry conjugation with alkynes. PTAD reagents are chemoselective for tyrosine over cysteine and lysine, enabling modification of small molecules, peptides, and proteins in biologically compatible aqueous buffers across a broad pH range—without heavy metal catalysts. The resulting tyrosine click linkage is highly stable, outperforming maleimides under heat, extreme pH, and in human plasma, making PTAD-azide ideal for robust, biocompatible bioconjugation.
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