6-(2-(Methylsulfonyl)pyrimidin-5-yl)hex-5-ynoic acid is a heterobifunctional crosslinker featuring a methylsulfonylpyrimidine moiety with exceptional chemoselectivity for cysteine and carboxylic acids. Its cysteine conjugates exhibit superior stability in aqueous media, plasma, and living cells, making this thiol-click reagent ideal for robust and precise bioconjugation applications.
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