APN-PEG4-DBCO is a heterobifunctional PEG linker combining an APN moiety with high cysteine selectivity and a DBCO group for strain-promoted azide–alkyne cycloaddition (SPAAC). Its stable APN–cysteine conjugates resist hydrolysis in aqueous media, human plasma, and living cells. Featuring a hydrophilic PEG4 spacer, it enhances solubility, reduces steric hindrance, and minimizes aggregation. Biocompatible and chemoselective, this linker enables rapid, copper-free click conjugation for antibody-drug conjugates and bioconjugation applications.
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