DBCO-PEG8-GGFG-DXD is a unique linker-payload construct for antibody–drug conjugates (ADCs). It features a DBCO handle for copper-free SPAAC conjugation with azide-modified antibodies, an 8-unit PEG spacer to enhance aqueous solubility, and a protease-cleavable GGFG tetrapeptide linker. The payload, DXD (exatecan derivative), is a highly potent DNA topoisomerase I inhibitor, enabling efficient intracellular release and targeted cytotoxicity in ADC applications.
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