3,4-Dibromo-Mal-PEG8-Val-Cit-PAB-MMAE serves as a cleavable linker-payload applied in the creation of antibody-drug conjugation. The dibromomaleimide group allows for two points of attachment because both of the bromine atoms can be substituted. The Val-Cit dipeptide is cleaved by cellular proteases like Cathepsin B within the cell to allow for efficient MMAE payload delivery via an elimination mechanism within the PAB structure. The PEG8 chain bolsters the water solubility of the molecule.
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