Infigratinib

Infigratinib

Infigratinib (BGJ-398; NVP-BGJ398) is a potent, orally available FGFR inhibitor with IC50 values of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. It also inhibits VEGFR2 (IC50 = 180 nM) while showing minimal activity against other kinases. Infigratinib suppresses proliferation in cancer cells overexpressing wild-type FGFR3 and inhibits tumor growth in an RT112 bladder cancer xenograft mouse model at doses of 10-30 mg/kg. Reagent grade, for research use only.

Molecular structure of the compound BP-43657
    • Unit
    • Price
    • Qty
    • 25 MG
    • $120.00
    • 50 MG
    • $210.00
    • 100 MG
    • $320.00
    • 250 MG
    • $540.00

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