Cedazuridine (E7727) is an orally active cytidine deaminase (CDA) inhibitor (IC50 = 0.4 µM) used in cancer research. It increases plasma decitabine levels by inhibiting its metabolism and, in combination with 5-azacytidine, reduces leukemic cell expansion in an AML mouse model. Cedazuridine is used in formulations with decitabine for treating myelodysplastic syndrome (MDS). Reagent grade, for research purpose.
Usually ships within 24 hours.