Acid-PEG4-GGFP-DXD is a unique tetrapeptide linker-payload applied in the creation of antibody-drug conjugates (ADCs). The carboxylic acid reacts with primary amines via activators like HATU. DXd, a derivative of exatecan, serves as a novel DNA topoisomerase I inhibitor that may be used as an ADC payload. The PEG4 units boost the solubility of the compound in aqueous media.
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