NHS-PEG4-GGFG-DXD is a unique tetrapeptide linker-payload used for the generation of antibody-drug conjugates (ADCs). The NHS is reactive with amine moieties. DXd, a derivative of exatecan, is a novel DNA topoisomerase I inhibitor that may be used as an ADC payload. The PEG4 units boost the solubility of the compound in aqueous media.
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