MC-Glu(OtBu)-Gly-Cit-PAB-OH is a cleavable tripeptide linker designed for exceptional bloodstream stability, resisting degradation and neutrophil protease activity while enabling traceless intracellular payload release. The peptide sequence contains glutamic acid, which is protected by a terminal t-butyl ester that can be deprotected under acidic conditions. Its maleimide group conjugates with cysteine-bearing biomolecules.
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