DBCO-PEG12-Val-Cit-PAB-MMAE is an ADC linker that integrates a click-reactive DBCO group, a protease-sensitive Val-Cit dipeptide, a self-immolative PAB motif, and a potent MMAE warhead. The DBCO group enables fast conjugation with azide groups, while the Val-Cit dipeptide is cleaved by proteases, triggering the elimination process within the PAB fragment to release MMAE into target cells. The PEG12 units elevate the hydrophilicity of the molecule. Reagent grade, for research use only.
Usually ships within 24 hours.