N-(C1-Mal)-N-bis(PEG2-t-butyl ester) serves as a branched PEG linker containing a maleimide group to react with thiol-containing biomolecules and two t-butyl ester groups, which can be deprotected under acidic conditions. The hydrophilic PEG spacer increases solubility in aqueous media. Branched linkers allow for more payload attachment to ADC.
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