Azide-PEG12-Val-Cit-PAB-MMAE is a cleavable antibody-drug conjugate (ADC) linker-payload construct. It features an azido group for copper-free click chemistry with alkyne-functionalized molecules, a cathepsin-sensitive Val-Cit dipeptide for controlled intracellular release, a self-immolative PAB linker, and the cytotoxic MMAE payload for targeted cancer therapy applications. Solubility in aqueous media is enhanced via the PEG12 linkage.
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