The MPLA structural analog, 3D(6-acyl)-PHAD , is the synthetic MPLA most closely related to the reported structure of MPL adjuvant used in GSK’s Adjuvant Systems AS01, AS02, and AS04. As with other synthetic MPLA analogs, it is structurally homogeneous and highly purified, and mimics the TLR4 agonist activity of bacterial MPLA.
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