The highly pure MPLA analog, Monophosphoryl 3-?deacyl lipid A ammonium salt, provides a homogeneous synthetic equivalent for the 3-deacylated MPLA derived from bacterial LPS. While comparable to bacterial MPLA and other synthetic MPLA analogs at eliciting an immune response in a liposomal adjuvant system (see bar graph), Monophosphoryl 3-?deacyl lipid A ammonium salt is less pyrogenic than its bacterial-derived mimic. Extensive preclinical testing with Monophosphoryl 3-?deacyl lipid A ammonium salt demonstrated equivalency to Monophosphoryl Lipid A.
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