Thalidomide-O-PEG2-azide represents a thalidomide-based building block, with a PEG2-linker and azide functional group, enabling conjugation with alkyne-functionalized linkers or target protein ligands via click chemistry. Ideal for creating PROTACs, it recruits the Cereblon (CRBN) E3 ligase to selectively polyubiquitinate and degrade specific cellular proteins through proteasomal pathways.
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