BP Lipid 528 is a novel, multifunctional, iso- methyl branched fatty acid TCL053 analog designed to mimic bacterial lipids. The ionizable head group consists a multichargeable 2-hydroxyethyl methylpiperazine moiety and a three carbon spacer. Four biodegradable ester linkages further accentuate the utility of this lipid for the formulation of lipid nanoparticles for delivery applications.
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