DBCO-Val-Ala-PAB-Exatecan

DBCO-Val-Ala-PAB-Exatecan

DBCO-Val-Ala-PAB-Exatecan serves as a cathepsin-cleavable Val-Ala dipeptide conjugated to an exatecan payload, a structural analog of camptothecin. The terminal DBCO partakes in copper-free click chemistry reactions with azides. DBCO-Val-Ala-PAB-Exatecan is a mixture of two isomers due to the rotation around C=N bond loser to the DBCO group.

Molecular structure of the compound BP-42740

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