Azido-PEG12-Amido-Val-Cit-PAB represents a distinct linker conjugate used in the creation of antibody-drug conjugates. The terminal azide group can undergo CuAAC or SPAAC with DBCO, BCN, and alkynes. The Val-Cit peptide will specifically be cleaved by Cathepsin B. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payload. Water solubility is bolstered via the PEG chain.
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