Progesterone-d9 is a deuterium-labeled form of progesterone, intended for use as an internal standard for the quantification of progesterone via GC- or LC-MS. Progesterone is the biosynthetic precursor for all other steroid hormones. It is synthesized from cholesterol through the action of desmolase in the mitochondria, producing pregnenolone, followed by Δ4,5-isomerase in the outer mitochondrial membrane and smooth endoplasmic reticulum of steroid-secreting cells. Progesterone activates the human progesterone receptor with an EC50 value of 0.5 nM.
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