mPEG-C-DMG, MW 2,000, is a PEGylated derivative of 1,2-dimyristoyl-sn-glycerol (1,2-DMG) used in combination with other lipids to create lipid nanoparticles (LNPs) for siRNA delivery. LNPs formulated with mPEG-C-DMG, MW 2,000 and encapsulating siRNA targeting programmed cell death protein ligand 1 (PD-L1) and PD-L2 effectively reduce PD-L1 and PD-L2 levels in monocyte-derived dendritic cells. This compound has also been utilized in the development of LNPs for siRNA-based vaccines.
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