Lipid OA2 (hydrochloride)

Lipid OA2 (hydrochloride)

Lipid OA2 is an ionizable cationic lipid that has been used in the generation of single-component lipid nanoparticles (LNPs) for the delivery of siRNA.1 LNPs containing lipid OA2 and siRNA targeting the gene encoding suppressor of cytokine signaling 1 (Socs1) decrease Socs1 expression by approximately 50% in isolated mouse bone marrow dendritic cells (BMDCs). Vaccination with ovalbumin-induced isolated mouse BMDCs transfected with LNPs composed of lipid OA2 and Socs1-targeting siRNA increases survival and decreases tumor volume in a B16-OVA murine melanoma model.

Molecular structure of the compound BP-42712
    • Unit
    • Price
    • Qty
    • 5 MG
    • $150.00
    • 10 MG
    • $220.00
    • 25 MG
    • $420.00
    • 50 MG
    • $730.00

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