C14-A1 is an ionizable cationic lipid utilized in the development of lipid nanoparticles (LNPs) for mRNA delivery. LNPs containing C14-A1 and mRNA encoding forkhead box protein P3 (FOXP3) enhance FOXP3 expression in primary human T cells. These LNPs also suppress the proliferation of primary human CD4+/CD8+ T cells, increase TGF-β1 secretion, and decrease IL-10 secretion from CD4+/CD8+ T cells.
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