(S)-C12-200 is an ionizable cationic lipid (pKa = 7.12) and an isomer of C12-200, used in the formulation of lipid nanoparticles (LNPs) for in vivo mRNA delivery. Intravenous administration of LNPs formulated with (S)-C12-200 and encapsulating mRNA encoding Cre recombinase results in a higher percentage of tdTomato+ hepatocytes, endothelial cells, and Kupffer cells in the livers of Ai14 mice compared to LNPs containing (R)-C12-200 with Cre mRNA.
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