C14-O2 is an ionizable cationic lipid (apparent pKa = 6.6) employed in the formulation of lipid nanoparticles (LNPs) for mRNA delivery both in vitro and in vivo. LNPs formulated with C14-O2 and encapsulating mRNA encoding a chimeric antigen receptor (CAR) effectively induce CAR expression and result in B cell aplasia in mice.
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