H1L1A1B3 is an ionizable lipid used in lipid nanoparticles (LNPs) for delivering circular RNA (circRNA) in vitro and in vivo. LNPs with H1L1A1B3 and circRNA encoding IL-12 outperform ALC-0315 in inducing IL-12 production and reducing tumor growth in a murine Lewis lung carcinoma model.
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