NHS ester-PEG4-Val-Cit-PAB-MMAF is a linker-payload conjugate that may be employed for antibody drug conjugates (ADCs). MMAF is an antitubulin agent that inhibits cell division by blocking the polymerization of tubulin. The Val-Cit will specifically be cleaved by Cathepsin B. The terminal NHS ester can react directly and efficiently with amine-containing compounds. The PEG4 chain provides enhanced water-solubility.
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