Miltefosine inhibits CTP:phosphocholine cytidylyltransferase (CCT) and reduces liposome-induced CCT activity in MDCK cell homogenates. It induces CCT translocation from the membrane to the cytosol and inhibits phosphatidylcholine biosynthesis in MDCK and HeLa cells. Miltefosine also inhibits phosphatidylserine-activated PKC and PMA-induced morphological changes and proliferation in MDCK cells.
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