CRBN-6-5-5-VHL is a selective degrader that utilizes the von Hippel-Lindau (VHL) system to target cereblon (CRBN). This compound demonstrates a strong potency for degradation while exhibiting minimal impact on the neo-substrates IKZF1 and IKZF3. Its structural design focuses on optimizing the interactions with the E3 ligase complex to enhance degradation efficiency.
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