Nutlin-3a (Rebemadlin) is the active enantiomer of Nutlin-3 and serves as a potent inhibitor of murine double minute 2 (MDM2) with an IC50 of 90 nM. It disrupts the MDM2-p53 interaction, leading to stabilization of the p53 protein and subsequent induction of cell autophagy and apoptosis. Nutlin-3a is valuable for investigating TP53 wild-type ovarian carcinomas due to its structural specificity in targeting these interactions.
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