N-Mal-N-bis(PEG4-acid-amido-PEG24-acid) functions as a maleimide PEG reagent with two terminal carboxylic acids and a maleimide (Mal) group. Maleimide (Mal) reacts specifically with sulfhydryl groups to form a stable thioether linkage when the pH is between 6.5 and 7.5. The terminal carboxylic acids can conjugate with amine-containing molecules in the presence of activators (e.g. HATU). The PEG linkages improve the compound's water solubility.
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