Picolyl azide-PEG4-NHS ester is a bifunctional PEG linker comprised of a picolyl moiety that assists with a copper-chelating system within its structure and an NHS ester that directly and efficiently reacts with amine-bearing moieties. Compared with conventional azides, picolyl azide will allow to use at least 10-fold less copper catalyst to yield the same click reaction rate as regular azide, because picolyl moiety can chelate Cu to raise the effective concentration of Cu(I) at the reaction site. The PEG4 chain improves the compound's water solubility.
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