DOTA-PEG5-TCO is a PEG linker containing DOTA and TCO moieties. TCO is a click chemistry handle that readily reacts with tetrazine groups on a target molecule. The DOTA group can be ionized and is susceptible to chelating di- and trivalent cations. DOTA can also be used for imaging diagnostic techniques. The half-life of TCO is short as it will naturally isomerize into CCO (cis-cycloctene) and lose the reactivity. TCO compound is not recommended for long term storage.
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